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Fatal anaphylactoid reaction after primary exposure to aprotinin

Department of Cardiac Surgery, Virgen de la Salud Hospital, Avda. Barber, 30, 45004 Toledo, Spain

*Corresponding author. Tel.: +34-925-269200; fax: +34-925-214860.

E-mail address: lopezalmodovar{at}yahoo.es (L.F. López Almodóvar).

Aprotinin is widely used to prevent bleeding, inhibit systemic inflammatory response and reduce blood transfusions after cardiac surgery. Because it is a bovine protein, aprotinin can induce hypersensitivity reactions. We report a case of fatal anaphylactoid reaction to primary aprotinin exposure in a woman who was admitted for mitral valve replacement. The possibility of anaphylactic reaction should be considered whenever aprotinin is used.

Key Words: Surgery complications; Surgery emergency; Resuscitation